Ferroportin is expressed on the mucous granule membrane of a subpopulation of goblet cells in the duodenum of the rat

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Ferroportin is a basolateral transporter involved in the release of iron from cells. In addition to expression on the basolateral membrane of enterocytes, ferroportin is also seen on the microvillus membrane. This led us to consider that ferroportin might be expressed by other cells of the intestine where it contributes to iron metabolism. Ferroportin gene and protein expression in rat duodenum was studied by in situ hybridisation and immunohistochemistry, respectively in rats with different efficiencies of iron absorption. Ferroportin mRNA localised to enterocytes of the villus only. Ferroportin was demonstrated in enterocytes and in 30% of goblet cells. In goblet cells it localised to the mucous granule membrane. In iron-loaded intestine some goblet cells contained iron suggesting, that ferroportin may transport iron into the mucous granule where it would be lost during discharge of mucous. The finding of ferroportin in iron deficient goblet cells also suggests an additional role to iron excretion.
Original languageEnglish
Pages (from-to)681-687
JournalHistology and Histopathology: cellular and molecular biology
Volume20
Issue number3
Publication statusPublished - 2005

Fingerprint Dive into the research topics of 'Ferroportin is expressed on the mucous granule membrane of a subpopulation of goblet cells in the duodenum of the rat'. Together they form a unique fingerprint.

  • Cite this