Background: Mitochondria send signals to the nucleus to modulate gene expression when mitochondrial function is perturbed. Results: Cyclin-dependent kinase E1 (CDKE1) was identified as an essential component in regulation of responses to perturbation of mitochondrial electron transport. Conclusion: Mitochondrial regulation is integrated with growth, energy, and other cellular stress signaling pathways. Significance: The identification of a molecular link between mitochondrial retrograde regulation and growth and stress signaling pathways. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Duncan, O., Day, D. A., Blanco, N. E., Strand, A., Whelan, J., & Ivanova, A. (2013). Cyclin-dependent kinase E1 (CDKE1) provides a cellular switch in plants between growth and stress responses. Journal of Biological Chemistry, 288(5), 3449-3459. https://doi.org/10.1074/jbc.M112.416727