Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System

Janice M. Fairchild, Bruce R. King, Geoffrey R. Ambler, Fergus J. Cameron, Elizabeth A. Davis, Timothy W. Jones, Westmead-Julie Klimek, Kristine Heels, Tracey Jopling

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension. Research Design and Methods: Children and adolescents with type 1 diabetes used the Medtronic MiniMed (TM) 640G pump as part of a randomized controlled trial. Data collected on a subgroup of participants on PLGM (suspend before low enabled) from CareLink (R) Therapy Management Software were analyzed to explore the time and duration of PLGM-initiated pump suspension. Day and nighttime were defined as 06:00 am to 10:00 pm and 10:00 pm to 6:00 am, respectively. Results: There were 20,183 suspend before low events in 8523 days (2.37 events/day). The mean suspend duration was 55.0 +/- 32.7 min (day 50.0 +/- 30.1, night 71.7 +/- 35.1; P <0.001). Although a 2-h pump suspension was more frequent at night (day 5%, night 18%), a patient-initiated resumption occurred more during day (day 34%, night 12%). SG values did not reach

Original languageEnglish
Pages (from-to)28-34
Number of pages7
JournalDiabetes Technology & Therapeutics
Volume21
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019
EventConference of the Australian-Pediatric-Endocrine-Group (APEG) (2017) - The Hotel Grand Chancellor, Hobart, Australia
Duration: 26 Nov 201729 Nov 2017
https://willorganise.eventsair.com/QuickEventWebsitePortal/2017-apeg-asm/website

Keywords

  • ADOLESCENTS
  • ALGORITHM
  • INDUCED HYPOGLYCEMIA
  • PREVENTION
  • PUMP THERAPY
  • Predictive Low-Glucose Management
  • REDUCTION
  • Sensor glucose
  • Suspend before low
  • Type 1 diabetes

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