• Source: Scopus
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Personal profile


Prof Thomas Fath is Deputy Director of the Dementia Research Centre and Professor in the Department of Biomedical Sciences of the Faculty of Medicine and Health Sciences at Macquarie University. Previous to this, he was the Head of the Neurodegeneration and Repair Unit (NRU) and Head of the Neuronal Culture Core Facility (NCCF) at UNSW. He received his PhD in 2002 from the University of Heidelberg, where he worked on the functional role of Tau phosphorylation in Alzheimer's disease. He then moved to The Scripps Research Institute at La Jolla (2003-2005, USA), shifting his research focus to the study of the actin cytoskeleton in neuronal function and morphogenesis. After this, Dr Fath continued his work on the actin cytoskeleton in neurons at the Children's Hospital at Westmead (2005-2008). In 2009, he took on a Research & Teaching position in the School of Medical Sciences at UNSW Sydney, where he established an ARC and NHMRC-funded research program, investigating cytoskeleton-associated patho-mechanisms of Neurodegenerative diseases and mechanisms of neurite regeneration.  

Research interests

The primary research focus of the lab is on the regulation of the cytoskeleton in injury and diseases of the central nervous system, including brain trauma, Alzheimer's Disease and motor neuron disease. For this, we employ cell and tissue cultures and genetically modified mice, combined with advanced imaging technologies. Recent outcome from our work demonstrates that distinct isoforms of the tropomyosin protein family regulate early processes of neuronal morphogenesis and that these proteins are key regulators of the cellular architecture in sub-cellular compartments of neuronal cells such as the growth cones of extending neurites in the developing and synaptic connections in the mature nervous system. Our research team investigates the actin cytoskeleton as potential drug target to provide protection and promote regeneration in the injured or diseased nervous system. Current projects include: 
Functional charachterisation of the synaptic actin cytoskeleton in Alzheimer's disease
Develop actin cytoskeleton targeting therapies for neurodegenerative diseases
Deciphering the functional role of the actin cytoskeleton in neuronal morphogenesis

Education/Academic qualification

The University of New South Wales

1 Jul 20141 Jun 2016

Heidelberg University


Heidelberg University


University of Wales

1 Sep 19961 Aug 1997

External positions

Executive Secretary

5 Dec 2018 → …

Conjoint Associate Professor

25 May 2018 → …

Chair, 'Cell Architecture' Special Interest Group

2018 → …

Organizer - Brain Awareness Week activities

Nov 2011 → …


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