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Personal profile

Personal profile

Dr Cahill studied Science at the University of New South Wales, graduating with BSc (Hons 1) in Zoology with a strong Biochemistry emphasis in 1987 and a PhD from the Department of Pathology, School of Medicine of the University of NSW, working on the transcriptional regulation of the c-fos gene as an external student based at the Medizinische Hochschule in Hannover, Germany. After finishing his doctoral thesis in late 1994 he remained in the same lab for another twelve months as a “post doctoral scientist” (postdoc) before moving back to Australia in late 1995.

Being interested in signal transduction events in the cytoplasm, he was captivated in 1996 by the then emerging field of proteomics; so much so that he moved from Canberra back to Germany where from 04/1997 to 01/2000 he established a proteomics laboratory as postdoc/group leader at the University of Tuebingen. That activity later developed into the present Tuebingen Proteomics Centre. However before that centre was officially opened he had left the academic world to co-found a proteomics-based biotechnology company called ProteoSys AG, based in Mainz. There he remained as Chief Research Officer until 2007, after which he ‘moved back home’ to re-enter academic life in Australia. Dr Cahill commenced as a biochemistry lecturer at CSU in Wagga Wagga in 2008. Since then he has served at different times as School Honours Coordinator and Chair of the School Research Committee, and is currently an elected staff representative serving on both Academic Senate and the CSU Research Committee. He teaches in the areas of nutritional metabolism, biochemistry, molecular cell biology, and genomics, proteomics and bioinformatics.

Dr. Cahill's research interests cover the healthy and pathological biology of the cell signalling system surrounding the protein "Progesterone Receptor Membrane Component 1". He has recently shown that PGRMC1 phosphorylation is involved in mitochondrial morphology and metabolic function, and in epigenetic gene regulation that drives cell phenotypical plasticity. PGRMC1's phosphorylated tyrosines appeared in evolution at the same time as the gastrulation organiser and derived specialised cell types, such as neurons. We are begining to understand the broad range of effects of PGRMC1 in diseases like cancer (Warburg effect metabolism) and neurodegeneration. For instance, it is emerging that Alzheimer's disease may be caused by perturbations in PGRMC1 function, which cause all of the downstream effects commonly researched (amyloid beta, Tau. ApoE, epigentics, glucose metabolism, and mitochondrial dysfunction). The future will attest whether these unorthodox statements bear the test of time (no other Australian Alzheimer's researcher would argue this). Dr. Cahill is confident that it will be so.

URL

Education/Academic qualification

The University of New South Wales

Feb 1991Aug 1994

Award Date: 6 Feb 1996

The University of New South Wales

19831987

Award Date: 9 May 1988

External positions

Scientific Advisor (http://cogrx.com/team/)

Aug 2013 → …

Chief Research Officer and Scientific Co-founder

Feb 2002Sep 2007

Postdoctoral Research Group Leader, Proteomics, Interfaculty Institute for Cell Biology

Apr 1997Jan 2000

Postdoctoral Researcher, John Curtin School of Medical Research

Jan 1996Feb 1997

Postdoctoral Researcher

Aug 1994Nov 1995

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Research Output

  • Thoughts on interactions between PGRMC1 and diverse attested and potential hydrophobic ligands

    Cahill, M. A. & Medlock, A. E., Jul 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 171, p. 11-33 22 p.

    Charles Sturt University

    Research output: Contribution to journalReview articleResearchpeer-review

  • Multiphoton fluorescence lifetime imaging microscopy reveals free-to-bound NADH ratio changes associated with metabolic inhibition

    Drozdowicz-Tomsia, K., Anwer, A. G., Cahill, M., Madlum, K. N., Maki, A. M., Baker, M. S. & Goldys, E. M., Aug 2014, In : Journal of Biomedical Optics. 19, 8, p. 1-13 13 p.

    Macquarie University, Charles Sturt University

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
  • Breast cancer proteomics reveals correlation between Estrogen Receptor status and differential phosphorylation of PGRMC1

    Neubauer, H., Clare, S. E., Wozny, W., Schwall, G. P., Poznanovic, S., Stegmann, W., Vogel, U., Sotlar, K., Wallwiener, D., Kurek, R., Fehm, T. & Cahill, M., 2008, In : Breast Cancer Research. 10, 5, p. 1-16 16 p.

    Charles Sturt University

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access