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Personal profile


Prof Gilles Guillemin has been working in the fields of Neuroimmunology and tryptophan metabolism for more than 20 years.

He is the Co-funder of the MND and Neurodegenerative Diseases Research Centre, The Co-funder of the Macquarie University MND Biobank and the Head of the Neuroinflammation group at Macquarie University.

Prof Guillemin’s team is one of the world’s leading research groups working on the involvement of the tryptophan catabolism (via the kynurenine pathway) in human neurodegenerative diseases.

He demonstrated the roles of this pathway in multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis, suicide…

He is the President of the International Society for Tryptophan Research and Editor-in-Chief of the International Journal for Tryptophan Research.

He has published more than 250 peer reviewed scientific articles. His current h-index is currently 66 and has more than 15.000 citations.

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Research Output

Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress

Halloran, M., Ragagnin, A. M. G., Vidal, M., Parakh, S., Yang, S., Heng, B., Grima, N., Shahheydari, H., Soo, K-Y., Blair, I., Guillemin, G. J., Sundaramoorthy, V. & Atkin, J. D., Oct 2020, In : Cellular and Molecular Life Sciences. 77, 19, p. 3859-3873 15 p.

Macquarie University

Research output: Contribution to journalArticleResearchpeer-review

  • Exosomes in Alzheimer’s disease: potential role as pathological mediators, biomarkers and therapeutic targets

    Lakshmi, S., Essa, M. M., Hartman, R. E., Guillemin, G. J., Sivan, S. & Elumalai, P., 25 Aug 2020, In : Neurochemical Research. 45, 11, p. 2553-2559 7 p.

    Macquarie University

    Research output: Contribution to journalReview articleResearchpeer-review

  • Possible role of tryptophan and melatonin in COVID-19

    Essa, M. M., Hamdan, H., Chidambaram, S. B., Al-Balushi, B., Guillemin, G. J., Ojcius, D. M. & Qoronfleh, M. W., 2020, In : International Journal of Tryptophan Research. 13, p. 1-2 2 p.

    Macquarie University

    Research output: Contribution to journalEditorialResearchpeer-review

    Open Access

    Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-β peptide generation

    Kim, W. S., Rahmanto, A. S., Kamili, A., Rye, K. A., Guillemin, G. J., Gelissen, I. C., Jessup, W., Hill, A. F. & Garner, B., 2 Jan 2007, In : Journal of Biological Chemistry. 282, 5, p. 2851-2861 11 p.

    Research output: Contribution to journalArticleResearchpeer-review

  • Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells

    Kim, W. S., Guillemin, G. J., Glaros, E. N., Lim, C. K. & Garner, B., Jun 2006, In : NeuroReport. 17, 9, p. 891-896 6 p.

    Research output: Contribution to journalArticleResearchpeer-review