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20172020

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Personal profile

Biography

With the award of a competitive Macquarie University Research Fellowship in 2014, I relocated to Macquarie Uni (MQ) to lead a new Brain Drug Delivery Group. There I chase my research dream and ambition to address one of the major challenges for brain disease therapy which is the successful delivery of therapeutic agents across the Blood Brain Barrier (BBB) – the BBB acts as a cellular barrier that prevents toxins, foreign materials and other dangerous molecules from entering the brain, however as a consequence this poses major challenges for getting therapeutic molecules into the brain.

To overcome this, my research program is developing advanced brain drug delivery system to efficiently transport the therapeutic drug across BBB into Brain for preclinical brain disease therapy evaluation with three core research streams: 1) development of novel nanoparticle-based blood–brain barrier (BBB) penetration mechanisms; 2) development of brain delivery systems based on the BBB mechanisms discovered in stream 1; 3) preclinical evaluation of therapies for brain diseases based on the delivery systems developed in stream 2. Each research stream is led by an outstanding ECR team member managing 1-2 PhD students, but I maintain overall stewardship by weekly meetings with my ECR team and students to ensure progress remains on track.

I contributed my expertise & knowledge to develop a new Blood-Brain-Barrier (BBB) penetration mechanism, as well as pioneering new strategies for brain drug delivery that led to an NHMRC Peter Doherty Fellowship (GNT1111822) and NHMRC-ARC Dementia Research Development Fellowship (GNT1111611) (Declined the former and took the Dementia one). In 2016, I discovered a novel glucose-transporter-mediated BBB penetration pathway and drug-controlled-release strategy in neuron, developing an effective brain delivery strategy (Glu-NPs; 2017) and attracting a Mason Foundation grant (GNT MAS2017F034) and NHMRC Project Grant (GNT1166024) for dementia therapy (both CIA; 2018). I lead a multidisciplinary team across MQ (myself, brain delivery; Dr Wright, Alzheimer’s disease (AD) biochemistry) and Western Sydney U (Dr. Chesworth, AD mouse behavior) for these funded projects.

Inspired by the unique capabilities of natural cells, I developed another novel biomimetic brain delivery strategy (Bio-NPs) with outstanding therapeutic effects for brain tumor therapy, which led to Australian Government Endeavour Research Fellowship (Recipient ID:6917_2018) to support visit Harvard University for six months to explore the potential applications in brain metastatic brain cancer therapy. Accordingly, I successfully secured an international grant as CIA ($620K AUD, GNT2018YFA0209800) to support a Phase 1 clinical trial. From 2019, I have been leading a 2nd multidisciplinary team across MQ, Henan province hospital, Huashan Hospital and Harvard Medical School for this project.

In recognizing my significant contributions to my research program, I was awarded four competitive fellowships(Macquarie University Research Fellowship, NHMRC Peter Doherty Fellowship, Australian Government Endeavour Research Fellowship, NHMRC-ARC Dementia Research Development Fellowship), many prestigious awards, eg, American Chem Society Rising star Award and MQ Early Career Researcher of the year in 2019.

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Research Output

A robust intrinsically green fluorescent poly(Amidoamine) dendrimer for imaging and traceable central nervous system delivery in zebrafish

Wang, G., Zhao, X., Wu, H., Lovejoy, D. B., Zheng, M., Lee, A., Fu, L., Miao, K., An, Y., Sayyadi, N., Ding, K., Chung, R. S., Lu, Y., Li, J., Morsch, M. & Shi, B., 2 Sep 2020, In : Small. 9 p.

Macquarie University

Research output: Contribution to journalArticleResearchpeer-review

  • Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy

    Ling, X., Tu, J., Wang, J., Shajii, A., Kong, N., Feng, C., Zhang, Y., Yu, M., Xie, T., Bharwani, Z., Aljaeid, B. M., Shi, B., Tao, W. & Farokhzad, O. C., 22 Jan 2019, In : ACS Nano. 13, 1, p. 357-370 14 p.

    Research output: Contribution to journalArticleResearchpeer-review

  • Intrinsically Fluorescent PAMAM Dendrimer as Drug carrier and Nanoprobe: Bioimaging and Neuron protection Study

    Wang, G., Babazadeh, A. & Shi, B., 2019, p. 70. 1 p.

    Macquarie University

    Research output: Contribution to conferencePosterResearchpeer-review

  • Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy

    Zheng, M., Tao, W., Zou, Y., Farokhzad, O. C. & Shi, B., 1 May 2018, In : Trends in Biotechnology. 36, 5, p. 562-575 14 p.

    Research output: Contribution to journalReview articleResearchpeer-review

  • Intracellular fate of nanoparticles with polydopamine surface engineering and a novel strategy for exocytosis-inhibiting, lysosome impairment-based cancer therapy

    Ding, L., Zhu, X., Wang, Y., Shi, B., Ling, X., Chen, H., Nan, W., Barrett, A., Guo, Z., Tao, W., Wu, J. & Shi, X., 8 Nov 2017, In : Nano letters. 17, 11, p. 6790-6801 12 p.

    Research output: Contribution to journalArticleResearchpeer-review