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Research interests

Thesis Title

Enzymatic Study of Lipid A Phosphoethanolamine Transferase from Pathogenic Neisseria

 

Thesis Summary

A wide variety of antibiotics are targeted to the bacterial membrane due to its unique arrangement and composition relative to the host mammalian membranes. Two pathogenic Neisseria species, N. meningitidis and N. gonorrhoeae, modify the lipid A (endotoxin) component found in the outer membrane through the addition of phosphoethanolamine (pEtN). This modification, catalysed by enzyme lipid A phosphoethanolamine transferase (EptA), confers resistance to polymyxin and the host immune system. Through enzymatic studies and protein crystallography, the catalytic mechanism of the enzyme will be studied and used as guidance for the development of potential inhibitor compounds against EptA.

 

Importance of Research

The main goal of this study is to understand the molecular mechanism of interaction between EptA, its substrates and potential inhibitors. This knowledge will lead to the development of novel therapeutic agents as anti-virulence factors  that will improve the clearance of N. gonorrhoeae and N. meningitidis by the human innate immune response or in combination with current antibiotics.   

Education/Academic qualification

The University of Western Australia

4 Oct 201623 Jan 2019

Award Date: 27 Jul 2019

Pelita Harapan University

10 Aug 20096 Sep 2013

Award Date: 6 Sep 2013

Research expertise keywords

  • Structural biology
  • Biochemistry
  • Enzymology

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