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Personal profile

Biography

Dr. Laird studies the pathogenesis of movement disorders with a particular focus on identifying and testing potential disease treatments. Her group has been successful at producing and characterising the world’s first zebrafish model of spinocerebellar ataxia type-3 (also known as Machado Joseph Disease, MJD). They are currently testing the effect of various drugs on these zebrafish with the aim of identifying a treatment for the disease.

Dr. Laird's full CV, with all grants and activities, can be accessed here.

Research interests

  • Developing transgenic zebrafish models of neurodegenerative diseases such as spinocerebellar ataxia-3 and motor neuron disease 
  • Role of proteolytic cleavage in the pathogenesis of spinocerebellar ataxia-3 
  • Potential of autophagy induction for the treatment of spinocerebellar ataxia-3 
  • Role of glutamate induced excitotoxicity in the pathogenesis of spinocerebellar ataxia-3

External positions

Senior Research Scientist

Jan 2010Feb 2016

Postdoctoral Fellow

May 2008Oct 2010

Casual Admin/Research Assistant

Jan 2002Jan 2007

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Research Output

The redox activity of protein disulfide isomerase inhibits ALS phenotypes in cellular and zebrafish models

Parakh, S., Shadfar, S., Perri, E. R., Ragagnin, A. M. G., Piattoni, C. V., Fogolín, M. B., Yuan, K. C., Shahheydari, H., Don, E. K., Thomas, C. J., Hong, Y., Comini, M. A., Laird, A. S., Spencer, D. M. & Atkin, J. D., 22 May 2020, In : iScience. 23, 5, p. 1-27 44 p., 101097.

Macquarie University

Research output: Contribution to journalArticleResearchpeer-review

Open Access